THE DOPAMINE-D1 RECEPTOR ANTAGONIST SCH-23390 DECREASES THE MESSENGER-RNA LEVELS OF THE TRANSCRIPTION FACTOR ZIF268 (KROX-24) IN ADULT-RAT INTACT STRIATUM - AN INSITU HYBRIDIZATION STUDY

被引：23

作者：

MAILLEUX, P

ZHANG, F

VANDERHAEGHEN, JJ

机构：

[1] Laboratory of Neurophysiology, Université Libre de Bruxelles, Brussels

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 02期

关键词：

TRANSCRIPTION FACTOR GENE; IMMEDIATE EARLY GENE; NGF1A; EGR-1; KROX-24; DOPAMINE RECEPTOR; STRIATUM; INSITU HYBRIDIZATION HISTOCHEMISTRY;

D O I：

10.1016/0304-3940(92)90590-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By in situ hybridization with an oligonucleotide probe, we have studied the cellular distribution of the messenger RNA encoding the transcription factor zif268 (krox-24) in the adult intact rat striatum and regulation of its synthesis by acute treatment with the dopamine D1 receptor antagonist SCH-23390. Zif268 mRNA was found in the striatal medium-sized neurons and not in the large cells. Its levels were decreased by SCH-23390, suggesting activation of this immediate early gene in the striatum through dopamine D, receptor stimulation.

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页码：182 / 184

页数：3

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