NEUROPATHIC PAIN SENSATIONS ARE DIFFERENTIALLY SENSITIVE TO DEXTRORPHAN

被引：89

作者：

TAL, M

BENNETT, GJ

机构：

[1] NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BETHESDA,MD 20892

[2] HEBREW UNIV JERUSALEM,HADASSAH DENT & MED SCH,DEPT ANAT,IL-91010 JERUSALEM,ISRAEL

来源：

NEUROREPORT | 1994年 / 5卷 / 12期

关键词：

ALLODYNIA; DEXTRORPHAN; HYPERALGESIA; NEUROPATHIC PAIN; NMDA ANTAGONIST;

D O I：

10.1097/00001756-199407000-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RATS with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

引用

页码：1438 / 1440

页数：3

共 17 条

[1] RESPONSE OF CHRONIC NEUROPATHIC PAIN SYNDROMES TO KETAMINE - A PRELIMINARY-STUDY [J].