ASYMMETRIC-SYNTHESIS .33. DIASTEREOSELECTIVE ALKYLATION OF N,N-SUBSTITUTED AMIDES

被引：12

作者：

MICOUIN, L

SCHANEN, V

RICHE, C

CHIARONI, A

QUIRION, JC

HUSSON, HP

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

[2] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

ASYMMETRIC SYNTHESIS; DIASTEREOSELECTIVE ALKYLATION OF AMIDES; PHENYLGLYCINOL DERIVATIVES;

D O I：

10.1016/0040-4039(94)85366-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of alpha-substituted amides 3 and 7-9 has been synthesized in enantiometrically pure form by diastereoselective alkylation of N-alkyl phenglyglycinol amides 2 and 4-6 respectively. A rigid amide enolate has been postulated to explain the observed diastereoselectivity.

引用

页码：7223 / 7226

页数：4

共 11 条

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QUIRION, JC
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[9] ASYMMETRIC-SYNTHESIS .31. SYNTHESIS OF 2-SUBSTITUTED PIPERAZINES FROM CHIRAL NON-RACEMIC LACTAMS
SCHANEN, V
RICHE, C
CHIARONI, A
QUIRION, JC
HUSSON, HP
[J]. TETRAHEDRON LETTERS, 1994, 35 (16) : 2533 - 2536
[10] SHELDRICK GM, 1976, SHELX PROGRAM CRYSTA

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