THE APOLIPOPROTEIN AICIII-AIV GENE-CLUSTER - SEQUENCE OF THE APOCIII-APOAIV INTERGENIC REGION

被引：12

作者：

OMORI, K

VERGNES, L

ZAKIN, MM

OCHOA, A

机构：

[1] INST PASTEUR,UNITE EXPRESS GENES EUCARYOTES,F-75724 PARIS 15,FRANCE

[2] TANABE SEIYAKU CO LTD,OSAKA 532,JAPAN

来源：

GENE | 1995年 / 159卷 / 02期

关键词：

ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; POLYMORPHISM; RFLP; PCR; 11Q23-QTER;

D O I：

10.1016/0378-1119(95)00063-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genes coding for human apolipoproteins AI, CIII and AIV are tandemly organised in a cluster on chromosome 11. The sequence of 4 kb of the 6.6-kb ApoCIII-ApoAIV intergenic region was unknown until now. Since different elements involved in the transcriptional regulation of the three genes of the cluster were previously identified in this region, we decided to sequence it, We present here the complete sequence of the region. Its availability will allow study of the transcriptional regulation of ApoCIII and ApoAIV at the molecular level. In addition, the use of PCR to study the polymorphic sites detected in the ApoCIII-ApoAIV intergenic region will now be possible. Some of these sites have been associated with lipid disorders and coronary heart disease.

引用

页码：231 / 234

页数：4

共 15 条

[1] DNA POLYMORPHISM HAPLOTYPES OF THE HUMAN APOLIPOPROTEIN APOA1-APOC3-APOA4 GENE-CLUSTER [J].