Genetic instability in patients with Hodgkin's disease undergoing chemotherapy

被引：26

作者：

Abdallah, JM ^{[1
]}

Lombardi, DP ^{[1
]}

Kirsch, IR ^{[1
]}

机构：

[1] NATL NAVAL MED CTR, NCI, MED ONCOL BRANCH, BETHESDA, MD 20889 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1995年 / 96卷 / 06期

关键词：

T cell; gene rearrangement; malignancy;

D O I：

10.1172/JCI118343

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have studied the effect of chemotherapy on the level of a particular kind of genetic instability in patients with Hodgkin's disease. The particular type of genetic instability assayed is exemplified by trans-rearrangements between two (rather than within one) T cell antigen receptor. 16 patients were studied during their course of treatment. Presentation samples were available for 13 of these patients; 9 of them showed an increase in the level of trans-rearrangements during their exposure to chemotherapeutic agents (P < 0.043). All patients for whom posttherapy samples were available (10 out of 16) showed a return to baseline levels of trans-rearrangements 1-5 mo after completion of therapy (P < 0.03). Thus, this assay appears to be a marker for the ''destabilizing'' effects of certain chemotherapeutic agents.

引用

页码：2744 / 2747

页数：4

共 19 条

[1] ELEVATED FREQUENCIES OF 6-THIOGUANINE-RESISTANT LYMPHOCYTES IN MULTIPLE-SCLEROSIS PATIENTS TREATED WITH CYCLOPHOSPHAMIDE - A PROSPECTIVE-STUDY [J].

AMMENHEUSER, MM ;

WARD, JB ;

WHORTON, EB ;

KILLIAN, JM ;

LEGATOR, MS .

MUTATION RESEARCH, 1988, 204 (03) :509-520

[2]

ARMITAGE P, 1971, STAT METHODS MED RES, P116

[3]

BODER E, 1985, ATAXIA TELANGIECTASI, P1

[4]

BUFFONE GJ, 1985, CLIN CHEM, V31, P164

[5] INVIVO SOMATIC MUTATION IN THE LYMPHOCYTES OF HODGKINS-DISEASE PATIENTS [J].

CAGGANA, M ;

LIBER, HL ;

MAUCH, PM ;

COLEMAN, CN ;

KELSEY, KT .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1991, 18 (01) :6-13

[6]

GATTI RA, 1971, CANCER-AM CANCER SOC, V28, P89, DOI 10.1002/1097-0142(197107)28:1<89::AID-CNCR2820280117>3.0.CO

[7]

2-Q

[8]

HAGMAR L, 1994, CANCER RES, V54, P2919

[9] GENETIC MECHANISMS IN TUMOR INITIATION AND PROGRESSION .12. CONSTITUTIONAL CHROMOSOME INSTABILITY AND CANCER RISK [J].

HEIM, S ;

JOHANSSON, B ;

MERTENS, F .

MUTATION RESEARCH, 1989, 221 (01) :39-51

[10] GENETIC INSTABILITY IN THE HUMAN-POPULATION - A WORKING HYPOTHESIS [J].

HSU, TC .

HEREDITAS, 1983, 98 (01) :1-9

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