Synthesis and biological activity of cyclohexenyl nucleosides. cis-5-(9H-purin-9-yl)-3-cyclohexenyl carbinols and their 8-azapurinyl analogs

被引：26

作者：

Konkel, MJ ^{[1
]}

Vince, R ^{[1
]}

机构：

[1] UNIV MINNESOTA,COLL PHARM,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 9-10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/15257779508010724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Azido-3-cyclohexenecarboxylic acid was reduced to an aminocyclohexenylcarbinol which was coupled with either 5-amino-4,6-dichloropyrimidine or 2-amino-4,6-dichloropyrimidine, giving 5-pyrimidinyl-3-cyclohexencarbinols. Condensation with triethylorthoformate or nitrous acid formed the purine and 8-azapurine ring systems, respectively. Anti-HIV-1 and cytotoxicity testing results are also described.

引用

页码：2061 / 2077

页数：17

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