EFFECT OF CHOLERA-TOXIN ON SMALL INTESTINAL MOTOR-ACTIVITY IN THE FED STATE

被引:14
作者
COWLES, VE
SARNA, SK
机构
[1] ZABLOCKI VET ADM MED CTR,5000 W NATL AVE,MILWAUKEE,WI 53295
[2] MED COLL WISCONSIN,DEPT SURG,MILWAUKEE,WI 53226
[3] MED COLL WISCONSIN,DEPT PHYSIOL,MILWAUKEE,WI 53226
[4] MED COLL WISCONSIN,SYST RES CTR,MILWAUKEE,WI 53226
关键词
diarrhea; intestinal transit; motility; oral rehydration solution; postprandial; propagating and nonpropagating contractions;
D O I
10.1007/BF01537414
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We sought to determine the effect of cholera toxin on small intestinal transit and motor activity in the fed state. Mean transit time increased after cholera toxin, but there was no change in mean amplitude, duration, and area of contractions. In contrast, there was a reduction in the total amplitude, duration, and area of contractions, and this was due to a decrease in frequency of contractions. The reduction in the total parameters of all contractions could be accounted for by a reduction in the same parameters for propagating contractions. The parameters of nonpropagating contraction were not different after cholera toxin. Also, there was a decrease in the distance of propagation of contractions. Our findings demonstrate that during the secretory state due to cholera toxin the small intestinal motor activity works in a compensatory mode to decrease transit and allow more time for absorption. © 1990 Plenum Publishing Corporation.
引用
收藏
页码:353 / 359
页数:7
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