EFFECT OF ENDOTHELIN-1 ON PULMONARY RESISTANCE IN RATS

被引:19
作者
MATSUSE, T
FUKUCHI, Y
SURUDA, T
NAGASE, T
OUCHI, Y
ORIMO, H
机构
[1] Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo
关键词
bronchoconstriction; pressure-sensitive body plethysmograph; spasmogen;
D O I
10.1152/jappl.1990.68.6.2391
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We examined the effect of endothelin-1 (ET-1), a novel 21-residue vasoconstrictor peptide, on pulmonary resistance (RL) in Wistar rats. The lung volume, tracheal flow, and transpulmonary pressure of tracheotomized and paralyzed rats were measured with a fluid-filled esophageal catheter and a pressure-sensitive body plethysmograph. RL was calculated by the method of von Neergaard. The femoral artery was cannulated to measure the mean arterial blood pressure. Intravenous bolus administration of synthetic ET-1 provoked a dose-dependent increase in RL in rats. The bronchoconstricting effect reached maximum at 500 pmol/kg. This bronchoconstriction was observed in <5 min, increased up to 15 min, and was sustained for 60 min. ET-1 increased the mean arterial blood pressure in a dose-dependent manner. We conclude that ET-1 is a hitherto unknown potent bronchoconstrictor that has a sustained effect in vivo. The potential physiological and pathophysiological role of this new peptide in the development of respiratory disease warrants further investigation.
引用
收藏
页码:2391 / 2393
页数:3
相关论文
共 8 条
[1]   HISTAMINE DOSE-RESPONSE CURVES IN GUINEA-PIGS [J].
HULBERT, WC ;
MCLEAN, T ;
WIGGS, B ;
PARE, PD ;
HOGG, JC .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 58 (02) :625-634
[2]  
KAMEYAMA M, 1989, American Review of Respiratory Disease, V139, pA106
[3]  
PAYNE A N, 1989, American Review of Respiratory Disease, V139, pA349
[4]  
TURNER N C, 1989, American Review of Respiratory Disease, V139, pA349
[5]   ENDOTHELIN, A NOVEL VASOCONSTRICTOR PEPTIDE, AS POTENT BRONCHOCONSTRICTOR [J].
UCHIDA, Y ;
NINOMIYA, H ;
SAOTOME, M ;
NOMURA, A ;
OHTSUKA, M ;
YANAGISAWA, M ;
GOTO, K ;
MASAKI, T ;
HASEGAWA, S .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 154 (02) :227-228
[6]  
VONNEERGAARD K, 1927, Z KLIN MED, V105, P51
[7]   A NOVEL POTENT VASOCONSTRICTOR PEPTIDE PRODUCED BY VASCULAR ENDOTHELIAL-CELLS [J].
YANAGISAWA, M ;
KURIHARA, H ;
KIMURA, S ;
TOMOBE, Y ;
KOBAYASHI, M ;
MITSUI, Y ;
YAZAKI, Y ;
GOTO, K ;
MASAKI, T .
NATURE, 1988, 332 (6163) :411-415
[8]  
YOSHIZUMI M, 1988, CIRCULATION S2, V78, P266