SISTER-CHROMATID EXCHANGES INDUCED BY 1.3-BUTADIENE AND ITS EPOXIDES IN CHO CELLS

被引：33

作者：

SASIADEK, M ^{[1
]}

JARVENTAUS, H ^{[1
]}

SORSA, M ^{[1
]}

机构：

[1] INST OCCUPAT HLTH,SF-00250 HELSINKI,FINLAND

来源：

MUTATION RESEARCH | 1991年 / 263卷 / 01期

关键词：

1,3-BUTADIENE; 3,4-EPOXY-1-BUTENE; 1,2-3,4-DIEPOXYBUTANE; SISTER-CHROMATID EXCHANGE; CHINESE HAMSTER OVARY CELLS;

D O I：

10.1016/0165-7992(91)90033-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sister-chromatid exchanges (SCEs) were analyzed in CHO cells after pulse treatment with 1,3-butadiene, 3,4-epoxy-1-butene (monoepoxybutene) and 1,2:3,4-diepoxybutane (diepoxybutane). A weak dose effect was observed after exposure to 1,3-butadiene but only in the presence of S9 mix. Monoepoxybutene and diepoxybutane were highly effective in inducing SCEs at concentrations of 0.1-1-mu-M both in the presence and in the absence of S9 mix. At higher concentrations the response was more pronounced without S9 mix.

引用

页码：47 / 50

页数：4

共 19 条

[1] INVITRO AND INVIVO GENOTOXICITY OF 1,3-BUTADIENE AND METABOLITES [J].