PREFERENTIAL EXCISION REPAIR AND NON-PREFERENTIAL PHOTOREACTIVATION OF PYRIMIDINE DIMERS IN THE C-RAS SEQUENCE OF CULTURED GOLDFISH CELLS

被引：20

作者：

KOMURA, J

MITANI, H

NEMOTO, N

ISHIKAWA, T

SHIMA, A

机构：

[1] UNIV TOKYO, FAC SCI, INST ZOOL, TOKYO 113, JAPAN

[2] JAPANESE FDN CANC RES, INST CANC, DEPT EXPTL PATHOL, TOSHIMA KU, TOKYO 170, JAPAN

来源：

MUTATION RESEARCH | 1991年 / 254卷 / 03期

关键词：

EXCISION REPAIR; FISH CELLS; PHOTOREACTIVATION; PYRIMIDINE DIMERS;

D O I：

10.1016/0921-8777(91)90056-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The time courses of excision repair and photoreaction of pyrimidine dimers induced by 254-nm UV were examined in the genome overall and in the c-ras sequence of RBCF-1 cells derived from a goldfish, by the use of UV endonuclease of Micrococcus luteus and alkaline agarose gel electrophoresis. Excision repair was more efficient in the ras sequence than in the genome overall, whereas no differences in efficiency of photoreactivation were detected. These results suggest that excision repair is affected by the accessibility of chromatin, while photoreaction is not.

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页码：191 / 198

页数：8

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