POSTMARKETING SURVEILLANCE STUDY OF PERMETHRIN CREME RINSE

被引:15
作者
ANDREWS, EB [1 ]
JOSEPH, MC [1 ]
MAGENHEIM, MJ [1 ]
TILSON, HH [1 ]
DOI, PA [1 ]
SCHULTZ, MW [1 ]
机构
[1] SARASOTA CTY HLTH DEPT,SARASOTA,FL
关键词
D O I
10.2105/AJPH.82.6.857
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background An observational, epidemiological study was undertaken to evaluate the safety of permethrin 1% creme rinse (Nix(TM)) for treatment of head lice infestations. Methods. Thirty-seven local public health departments enrolled a total of 38 160 patients for 47 578 treatments with permethrin or other pediculicides from September 1, 1986, through January 31, 1988. Follow-up safety information was collected between 7 and 14 days following treatment via return visit or telephone contact. Results. One hundred three adverse events were reported among 41 955 evaluable treatments. The rates of reported adverse events were 2.2 per 1000 treatments among permethrin treatments, 3.4 per 1000 treatments among lindane treatments, and 1.5 per 1000 treatments among other over-the-counter treatments. No serious, unexpected adverse events were detected in the 18 950 patients treated with permethrin. Conclusions. This study confirmed the safety profile of permethrin in conditions of general use, as seen in clinical trials. Postmarketing safety monitoring in public health departments of drugs used to treat public health conditions was shown to be feasible.
引用
收藏
页码:857 / 861
页数:5
相关论文
共 7 条
[1]   COMPARATIVE-STUDY OF PERMETHRIN-1-PERCENT CREME RINSE AND LINDANE SHAMPOO FOR THE TREATMENT OF HEAD LICE [J].
BOWERMAN, JG ;
GOMEZ, MP ;
AUSTIN, RD ;
WOLD, DE .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1987, 6 (03) :252-255
[2]   1-PERCENT PERMETHRIN CREAM RINSE VS 1-PERCENT LINDANE SHAMPOO IN TREATING PEDICULOSIS CAPITIS [J].
BRANDENBURG, K ;
DEINARD, AS ;
DINAPOLI, J ;
ENGLENDER, SJ ;
ORTHOEFER, J ;
WAGNER, D .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1986, 140 (09) :894-896
[3]  
JURANEK DD, 1977, SCABIES PEDICULOSIS, P168
[4]   EPIDEMIC OF PEDICULOSIS CAPITIS [J].
SLONKA, GF ;
FLEISSNER, ML ;
BERLIN, J ;
PULEO, J ;
HARROD, EK ;
SCHULTZ, MG .
JOURNAL OF PARASITOLOGY, 1977, 63 (02) :377-383
[5]   EPIDEMIOLOGY OF AN OUTBREAK OF HEAD LICE IN GEORGIA [J].
SLONKA, GF ;
MCKINLEY, TW ;
MCCROAN, JE ;
SINCLAIR, SP ;
SCHULTZ, MG ;
HICKS, F ;
HILL, N .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1976, 25 (05) :739-743
[6]  
STROM BL, 1990, CLIN PHARMACOL THER, V48, P598
[7]  
Taplin D, 1986, Pediatr Dermatol, V3, P344, DOI 10.1111/j.1525-1470.1986.tb00538.x