COMPARISON OF THE DIAGNOSTIC UTILITY OF TIMED SERIAL (SLOPE) CREATINE-KINASE MEASUREMENTS WITH CONVENTIONAL SERUM TESTS IN THE EARLY DIAGNOSIS OF MYOCARDIAL-INFARCTION

被引：13

作者：

LEUNG, FY ^{[1
]}

GRIFFITH, AP ^{[1
]}

JABLONSKY, G ^{[1
]}

HENDERSON, AR ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO HOSP,DEPT MED,LONDON N6A 5A5,ONTARIO,CANADA

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1991年 / 28卷

关键词：

RECEIVER-OPERATING CHARACTERISTIC CURVES; LIKELIHOOD RATIO ANALYSIS; CREATINE KINASE ISOENZYMES;

D O I：

10.1177/000456329102800113

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We compared the diagnostic utility of recently proposed slope assays for serum creatine kinase and creatine kinase-2 with the optimized decision threshold assays. The former approach has been claimed to be superior to any other single diagnostic technique. We show, by ROC curve and likelihood ratio analyses, that the total creatine kinase slope assay possesses the same diagnostic power, when confidence intervals are used, as the optimized decision threshold assay. Moreover, slope assays of creatine kinase-2 were diagnostically inferior to the optimized decision threshold assays. Indeed, these latter, optimized, assays have the highest likelihood ratios for a positive test result of the available assays, and they should always be used in situations of diagnostic doubt.

引用

页码：78 / 82

页数：5

共 12 条

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