BLOOD-BRAIN-BARRIER PERMEABILITY - REGIONAL ALTERATIONS AFTER ACUTE AND CHRONIC ADMINISTRATION OF ETHINYL ESTRADIOL

被引：20

作者：

ZIYLAN, YZ ^{[1
]}

LEFAUCONNIER, JM ^{[1
]}

BERNARD, G ^{[1
]}

BOURRE, JM ^{[1
]}

机构：

[1] FAC MED ISTANBUL,DEPT PHYSIOL,ISTANBUL,TURKEY

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Blood-brain barrier; Cerebral capillary; Cerebrovascular space; Estrogen; Permeability-surface area product;

D O I：

10.1016/0304-3940(90)90621-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study we measured the effect of acute and chronic estrogen treatment on cerebrovascular permeability to sucrose and inulin. Animals were subcutaneously injected once with 0.1 μg/rat of ethinyl estradiol or injected daily with the same drug dose for 3 weeks. Control rats received the same amount of arachis oil vehicle. Three weeks treatment but not the single injection of ethinyl estradiol produced significant increases in the cerebrovascular permeability-surface area product for sucrose and inulin in almost all brain regions. © 1990.

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页码：181 / 184

页数：4

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