A SHORT AND PRACTICAL SYNTHESIS OF 1-DEOXYNOJIRIMYCIN

被引：25

作者：

BEHLING, J ^{[1
]}

FARID, P ^{[1
]}

MEDICH, JR ^{[1
]}

SCAROS, MG ^{[1
]}

PRUNIER, M ^{[1
]}

WEIER, RM ^{[1
]}

KHANNA, I ^{[1
]}

机构：

[1] GD SEARLE & CO,DEPT MOLEC & CELL BIOL,SKOKIE,IL 60077

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 12-13期

关键词：

D O I：

10.1080/00397919108021285

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potent glucosidase inhibitor 1-deoxynojirimycin was synthesized from L-sorbose using a short synthesis and only one protecting group. The last step, which constituted the removal of an acetonide protecting group and an intramolecular reductive amination, was accomplished on an acidic Ion-exchange resin. This provided a synthesis capable of being operated on a multi-kilogram scale.

引用

页码：1383 / 1386

页数：4

共 10 条

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