A NEW ANGIOGENESIS INHIBITOR, FR-111142

被引：20

作者：

OTSUKA, T

SHIBATA, T

TSURUMI, Y

TAKASE, S

OKUHARA, M

TERANO, H

KOHSAKA, M

IMANAKA, H

机构：

[1] Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki 300-26, 5-2-3 Tokodai, Tsukuba

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.348

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

FR-111142 is a new angiogenesis inhibitor produced by a fungus Scolecobasidium arenarium F-2015. FR-111142 inhibited endothelial cell proliferation in vitro and angiogenesis in the growing chick chorioallantoic membrane model in vivo. Further, FR-111142 also suppressed the solid tumor growth in mice.

引用

收藏

页码：348 / 354

页数：7

相关论文

共 14 条

[1] A NEW CLASS OF STEROIDS INHIBITS ANGIOGENESIS IN THE PRESENCE OF HEPARIN OR A HEPARIN FRAGMENT [J].

CRUM, R ;

SZABO, S ;

FOLKMAN, J .

SCIENCE, 1985, 230 (4732) :1375-1378

[2]

ELLIS MB, 1976, MORE DEMATIACEOUS HY, P194

[3] TUMOR ANGIOGENESIS [J].

FOLKMAN, J .

ADVANCES IN CANCER RESEARCH, 1985, 43 :175-203

[4] ANGIOSTATIC STEROIDS - METHOD OF DISCOVERY AND MECHANISM OF ACTION [J].

FOLKMAN, J ;

INGBER, DE .

ANNALS OF SURGERY, 1987, 206 (03) :374-383

[5] SYNTHETIC ANALOGS OF FUMAGILLIN THAT INHIBIT ANGIOGENESIS AND SUPPRESS TUMOR-GROWTH [J].

INGBER, D ;

FUJITA, T ;

KISHIMOTO, S ;

SUDO, K ;

KANAMARU, T ;

BREM, H ;

FOLKMAN, J .

NATURE, 1990, 348 (6301) :555-557

[6]

KOHLMEYER J, 1979, MARINE MYCOLOGY HIGH, P486

[7] ISOLATION OF A CARTILAGE FACTOR THAT INHIBITS TUMOR NEOVASCULARIZATION [J].

LANGER, R ;

BREM, H ;

FALTERMAN, K ;

KLEIN, M ;

FOLKMAN, J .

SCIENCE, 1976, 193 (4247) :70-72

[8] INHIBITION OF HUMAN-ENDOTHELIAL CELL-PROLIFERATION BY GOLD COMPOUNDS [J].

MATSUBARA, T ;

ZIFF, M .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (05) :1440-1446

[9] A HIGHLY POTENT ANTIANGIOGENIC ACTIVITY OF RETINOIDS [J].

OIKAWA, T ;

HIROTANI, K ;

NAKAMURA, O ;

SHUDO, K ;

HIRAGUN, A ;

IWAGUCHI, T .

CANCER LETTERS, 1989, 48 (02) :157-162

[10] POWERFUL ANTIANGIOGENIC ACTIVITY OF HERBIMYCIN-A (NAMED ANGIOSTATIC ANTIBIOTIC) [J].

OIKAWA, T ;

HIROTANI, K ;

SHIMAMURA, M ;

ASHINOFUSE, H ;

IWAGUCHI, T .

JOURNAL OF ANTIBIOTICS, 1989, 42 (07) :1202-1204