INCREASED PENETRATION OF AMANITINE INTO HEPATOCYTES WHEN CONJUGATED WITH ALBUMIN

被引：7

作者：

BONETTI, E ^{[1
]}

DERENZINI, M ^{[1
]}

FIUME, L ^{[1
]}

机构：

[1] UNIV BOLOGNA, IST PATOL GEN, VIA SAN GIACOMO 14, I-40126 BOLOGNA, ITALY

来源：

ARCHIVES OF TOXICOLOGY | 1976年 / 35卷 / 01期

关键词：

D O I：

10.1007/BF00333987

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The amount of amanitine able to cause the specific nuclear lesions in mouse hepatocytes is 10 times lower when amanitine is administered conjugated to albumin instead of being injected as free toxin.

引用

页码：69 / 73

页数：5

共 20 条

[1] SELECTIVE KILLING OF MACROPHAGES BY AMANITIN-ALBUMIN CONJUGATES [J].

BARBANTIBRODANO, G ;

FIUME, L .

NATURE-NEW BIOLOGY, 1973, 243 (130) :281-283

[2]

BENACERRAF B, 1957, BRIT J EXP PATHOL, V38, P35

[3] LESIONS IN CELLS OF PROXIMAL CONVOLUTED TUBULES IN RAT-KIDNEY INDUCED BY AMANITIN-ALBUMIN CONJUGATE [J].

BONETTI, E ;

DERENZINI, M ;

FIUME, L .

VIRCHOWS ARCHIV ABTEILUNG B ZELLPATHOLOGIE, 1974, 16 (01) :71-78

[4] INCREASED TOXICITY OF BETA-AMANITIN WHEN BOUND TO A PROTEIN [J].

CESSI, C ;

FIUME, L .

TOXICON, 1969, 6 (04) :309-+

[5]

DERENZINI M, 1973, LAB INVEST, V29, P150

[6]

FAULSTICH H, 1973, DEUT MED WOCHENSCHR, V98, P2258

[7] SELECTIVE TOXICITY OF AMANITIN-ALBUMIN CONJUGATES FOR MACROPHAGES [J].

FIUME, L ;

BARBANTI.G .

EXPERIENTIA, 1974, 30 (01) :76-77

[8] AMANITINS - CHEMISTRY AND ACTION [J].

FIUME, L ;

WIELAND, T .

FEBS LETTERS, 1970, 8 (01) :1-+

[9] PRODUCTION OF ANTIBODIES TO AMANITINS AS BASIS FOR THEIR RADIOIMMUNOASSAY [J].

FIUME, L ;

BUSI, C ;

CAMPADELLIFIUME, G ;

FRANCESCHI, C .

EXPERIENTIA, 1975, 31 (10) :1233-1234

[10]

FIUME L, 1969, BRIT J EXP PATHOL, V50, P270

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