ISOLATION AND PROPERTIES OF A PHOSPHODIESTERASE FROM NEWBORN MOUSE SKIN

The determination of enzyme levels in skin tissue represents 1 approach towards an understanding of skin disease. In most cases, a relatively large amount of tissue is needed to carry out such determinations, and these assays cannot usually be made on small amounts of tissue from a conventional 3 mm. punch biopsy procedure. The greatly increased sensitivity of fluorometric methods to assay skin enzymes makes studies with small amounts of skin tissue feasible.