COMPLETE NUCLEOTIDE-SEQUENCE OF A GENOMIC CLONE ENCODING HLA-B35 ISOLATED FROM A CAUCASIAN INDIVIDUAL OF HISPANIC ORIGIN - IDENTIFICATION OF A NEW VARIANT OF HLA-B35

被引:23
作者
CHERTKOFF, LP [1 ]
HERRERA, M [1 ]
FAINBOIM, L [1 ]
SATZ, ML [1 ]
机构
[1] UNIV BUENOS AIRES,FAC MED,DEPT MICROBIOL,BUENOS AIRES,ARGENTINA
关键词
CLASS-I GENE; HEPATITIS-B VIRUS; HLA-A; MOLECULAR ANALYSIS; LYMPHOCYTES-T; ANTIGENS; SUBTYPES; EXPRESSION; ALLELES; TRANSCRIPTION;
D O I
10.1016/0198-8859(91)90020-A
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The primary structure of an HLA class I genomic clone isolated from a homozygous HLA-B35 Caucasian individual of hispanic origin was determined. The nucleotide sequence of exons 1, 2, 4, 5, 6, and 7 is identical to that of the HLA-B35 allele of Oriental origin reported previously. Exon 3 differs in only three nucleotides present in a stretch of 23 bp. These changes introduce three amino acid substitutions in residues 109 (Leu --> Phe), 114 (Asp --> Asn), and 116 (Ser --> Tyr), two of which (114 and 116) are located in one of the beta-sheets at the bottom of the peptide binding site. The nature of these replacements in this HLA-B35 variant is likely to affect peptide binding and recognition by T lymphocytes. Introns 1, 2, 3, 4, 5, and 6 from this genomic clone are identical to those present in HLA-Bw58, further confirming the evolutionary origin of HLA-B35.
引用
收藏
页码:153 / 158
页数:6
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