LONG-TERM TREATMENT OF CHRONIC HEPATITIS-C WITH INTERFERON-ALFA-2B - DISAPPEARANCE OF HCV-RNA IN A PILOT-STUDY OF 8 HEMOPHILIA PATIENTS

被引：7

作者：

BRESTERS, D

MAUSERBUNSCHOTEN, EP

CUYPERS, HTM

HAN, JH

JANSEN, PLM

CHAMULEAU, RAFM

HOUGHTON, M

REESINK, HW

机构：

[1] VAN CREVELD CLIN,BILTHOVEN,NETHERLANDS

[2] CHIRON CORP,EMERYVILLE,CA

[3] UNIV AMSTERDAM,ACAD MED CTR,1105 AZ AMSTERDAM,NETHERLANDS

来源：

GUT | 1993年 / 34卷 / 02期

关键词：

D O I：

10.1136/gut.34.2_Suppl.S124

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This pilot study was designed to establish the effect of long term alpha interferon treatment in haemophilia patients with chronic hepatitis C. Overall, three of eight (37.5%) patients showed a complete response, three of eight (37.5%) a transient response, and two of eight (25.0%) no response. HCV-RNA detection by polymerase chain reaction was more sensitive in detecting relapse than alanine aminotransferase (ALT) activity measurement, suggesting that current interferon schedules based on the ALT response should be re-evaluated critically.

引用

页码：S124 / S125

页数：2

共 2 条

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[2] CONFIRMATION OF HEPATITIS-C VIRUS-INFECTION BY NEW 4-ANTIGEN RECOMBINANT IMMUNOBLOT ASSAY [J].

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CUYPERS, HTM ;

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QUAN, S ;

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WINKEL, I ;

MULDERFOLKERTS, D ;

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SCHAASBERG, W ;

LEENTVAARKUYPERS, A ;

POLITO, A ;

HOUGHTON, M ;

LELIE, PN .

LANCET, 1991, 337 (8737) :317-319

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