INFLUENCE OF BILE ON CYCLOSPORINE ABSORPTION FROM MICROEMULSION FORMULATION IN PRIMARY LIVER-TRANSPLANT RECIPIENTS

被引：15

作者：

WINKLER, M

RINGE, B

OLDHAFER, K

KATTNER, A

FARBER, L

MAIBUCHER, A

WONIGEIT, K

PICHLMAYR, R

机构：

[1] Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, D-30625

[2] Sandoz AG, Nürnberg

来源：

TRANSPLANT INTERNATIONAL | 1995年 / 8卷 / 04期

关键词：

SANDIMMUN NEORAL; LIVER TRANSPLANTATION; BILE;

D O I：

10.1007/BF00346888

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We analysed the absorption, after oral application, of a new galenic form of cyclosporin A (CyA-NOF) in liver-grafted patients (n = 12) during the Ist week (days 2-4) after transplantation. Pharmacokinetic profiling was performed with an open or clamped T tube in situ or with the T tube absent. The pharmacokinetic parameters of CyA-NOF were influenced by T tube clamping and bile diversion. The highest AUG, C-max and earliest T values were found in patients without a T-max tube in situ, indicating that absorption of CyA-NOF in patients during the early course after liver transplantation is not bile-independent. CyA-NOF, at a dose of 7.5 mg/kg, was enterally absorbed with appropriate AUC and C-max levels. Patients receiving a starting dose of 7.5 mg/kg were successfully maintained on CyA-NOF during the subsequent clinical course.

引用

页码：324 / 326

页数：3

共 5 条

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[4] Trull A.K., Tan K.K.C., Uttridge J., Tredger J.M., Cyclosporine absorption from microemulsion formulation in a liver transplant recipient, Lancet, 341, (1993)
[5] Winkler M., Ringe B., Schneider K., Maibucher A., Farber L., Wietholtz H., Manns M., Pichmayr R., Enhanced bioavailability of cyclosporine using a new oral formulation (Sandimmun optoral) in a liver-grafted patient with severe cholestasis, Transpl Int, 7, pp. 147-148, (1994)

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