SUCCESSFUL PASSIVE AND ACTIVE IMMUNIZATION OF CYNOMOLGUS MONKEYS AGAINST HEPATITIS-E

被引:161
作者
TSAREV, SA
TSAREVA, TS
EMERSON, SU
GOVINDARAJAN, S
SHAPIRO, M
GERIN, JL
PURCELL, RH
机构
[1] UNIV SO CALIF,RANCHO LOS AMIGOS HOSP,PATHOL & CLIN LABS,DOWNEY,CA 90242
[2] BIOQUAL INC,ROCKVILLE,MD 20850
[3] GEORGETOWN UNIV,SCH MED,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852
关键词
D O I
10.1073/pnas.91.21.10198
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Virtually full protection against hepatitis E and partial or complete protection against infection with hepatitis E virus (HEV) were achieved in passively or actively immunized cynomolgus monkeys. Hepatitis, viremia, and shedding of the virus in feces were detected in all nonimmunized animals that were challenged with HEV. HEV titers detected by reverse transcriptase PCR were higher in feces than in serum of nonimmunized animals. Anti-HEV antibody titers at the time of challenge ranged between 1:40 acid 1:200 in animals passively immunized with convalescent plasma from a cynomolgus monkey previously infected with HEV and between 1:100 and 1:10,000 in animals actively immunized with a recombinant 55-kDa open reading frame 2 protein. The estimated 50% protective titer of passively acquired anti-HEV antibodies was 1:40. Although only one of four passively immunized animals showed histopathologic evidence of hepatitis, all four were infected after challenge; however, the titers of HEV in serum and feces were lower in the passively immunized animals than in the nonimmunized group. The actively immunized animals developed neither hepatitis nor viremia when challenged with HEV and virus was either not detected or was present in low titer in feces. The protective response was a function of the ELISA anti-HEV antibody titer at the time of challenge and the immunization schedule.
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页码:10198 / 10202
页数:5
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