Identification and characterization of a new member of the TNF family that induces apoptosis

被引：2920

作者：

Wiley, SR ^{[1
]}

Schooley, K ^{[1
]}

Smolak, PJ ^{[1
]}

Din, WS ^{[1
]}

Huang, CP ^{[1
]}

Nicholl, JK ^{[1
]}

Sutherland, GR ^{[1
]}

Smith, TD ^{[1
]}

Rauch, C ^{[1
]}

Smith, CA ^{[1
]}

Goodwin, RG ^{[1
]}

机构：

[1] WOMENS & CHILDRENS HOSP,DEPT CYTOGENET & MOLEC GENET,CTR MED GENET,ADELAIDE,SA 5006,AUSTRALIA

来源：

IMMUNITY | 1995年 / 3卷 / 06期

关键词：

D O I：

10.1016/1074-7613(95)90057-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin.

引用

页码：673 / 682

页数：10

共 46 条

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