Metal ion induced autoimmunity

被引：122

作者：

Griem, P

Gleichmann, E

机构：

[1] Medical Institute of Environmental Hygiene, Department of Immunology, D-40225 Düsseldorf

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 06期

关键词：

D O I：

10.1016/0952-7915(95)80056-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechanism for activation of 'metal-specific' T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.

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页码：831 / 838

页数：8

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