HAPLOTYPE ANALYSIS AND POLYMORPHIC FREQUENCY DATA AT 2 FACTOR-IX LOCI (F9-192 AND F9-HHA1) IN A CHINESE POPULATION

被引：2

作者：

CHEN, SH ^{[1
]}

WANG, NS ^{[1
]}

SCHOOF, J ^{[1
]}

SCOTT, CR ^{[1
]}

机构：

[1] CHILDRENS HOSP & MED CTR,SEATTLE,WA

来源：

HUMAN HEREDITY | 1992年 / 42卷 / 03期

关键词：

FACTOR-IX; HEMOPHILIA-B; CHINESE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

D O I：

10.1159/000154069

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene frequencies and haplotypes for two factor IX markers, F9-192 and F9-Hha1, were determined in a Chinese population. The frequencies for F9-192 are 0.86 for A and 0.14 for G. For F9-Hha1, the gene frequencies are 0.69 for - and 0.31 for +. Haplotype analysis revealed that the two polymorphic sites are in linkage equilibrium and, thus, are useful markers for genetic counseling of Asian families in which hemophilia B exists.

引用

页码：204 / 205

页数：2

共 7 条

[1]

BROWNLEE GG, 1988, RECENT ADV HAEMATOL, V15, P251

[2] AN INTRAGENIC DELETION OF THE FACTOR-IX GENE IN A FAMILY WITH HEMOPHILIA-B [J].

CHEN, SH ;

YOSHITAKE, S ;

CHANCE, PF ;

BRAY, GL ;

THOMPSON, AR ;

SCOTT, CR ;

KURACHI, K .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (06) :2161-2164

[3]

LASALLE C, 1990, CLIN GENET, V38, P434

[4]

REINER AP, 1990, HUM GENET, V86, P87

[5]

TANIMOTO M, 1989, BLOOD, V74, pA251

[6]

WINSHIP PR, 1989, LANCET, V1, P631

[7] NUCLEOTIDE-SEQUENCE OF THE GENE FOR HUMAN FACTOR-IX (ANTIHEMOPHILIC FACTOR-B) [J].

YOSHITAKE, S ;

SCHACH, BG ;

FOSTER, DC ;

DAVIE, EW ;

KURACHI, K .

BIOCHEMISTRY, 1985, 24 (14) :3736-3750

← 1 →