EXPRESSION OF CELL-ADHESION MOLECULES ALPHA-2, ALPHA-5 AND ALPHA-6 INTEGRIN, E-CADHERIN, N-CAM AND CD-44 IN RENAL-CELL CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY

被引：53

作者：

TERPE, HJ ^{[1
]}

TAJROBEHKAR, K ^{[1
]}

GUNTHERT, U ^{[1
]}

ALTMANNSBERGER, M ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4058 BASEL,SWITZERLAND

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 422卷 / 03期

关键词：

CELL ADHESION MOLECULES; IMMUNOHISTOLOGY; RENAL CELL CARCINOMA;

D O I：

10.1007/BF01621805

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Renal cell carcinoma is known to metastasize early independent of tumour grade. Invasion of the renal vein plays an important role in the prognosis. Cell adhesion molecules have been investigated, including the expression of alpha-2, alpha-5, and alpha-6 integrin, E-cadherin, neural-cell adhesion molecule and CD-44 in 34 renal cell carcinomas, using the alkaline phosphatase-antialkaline phosphatase technique. Our results indicate a differential expression of these cell adhesion molecules (alpha-2, alpha-5 and E-cadherin) depending on histological type and tumour grade.

引用

页码：219 / 224

页数：6

共 23 条

[1] DISSECTING TUMOR-CELL INVASION - EPITHELIAL-CELLS ACQUIRE INVASIVE PROPERTIES AFTER THE LOSS OF UVOMORULIN-MEDIATED CELL CELL-ADHESION [J].