AUTOANTIBODY SPECIFIC FOR A THYROGLOBULIN EPITOPE INDUCING EXPERIMENTAL AUTOIMMUNE-THYROIDITIS OR ITS ANTIIDIOTYPE CORRELATES WITH THE DISEASE

被引：16

作者：

TANG, H ^{[1
]}

BEDIN, C ^{[1
]}

TEXIER, B ^{[1
]}

CHARREIRE, J ^{[1
]}

机构：

[1] HOP COCHIN, INSERM, U283, 27 RUE FG ST JACQUES, F-75674 PARIS 14, FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 07期

关键词：

D O I：

10.1002/eji.1830200719

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to elucidate the role of anti‐thyroglobulin (Tg) autoantibodies (A‐Ab) in experimental autoimmune thyroiditis (EAT), a kinetic study was conducted in EAT‐susceptible (CBA/J) and non‐susceptible (C57BL/6) strains of mice. From day 0 to 70 post‐Tg immunization, titers of A‐Ab to Tg and to the linear 5‐10‐kDa Tg tryptic fragment inducing EAT as well as anti‐idiotypic A‐Ab representing the internal image of the thyroidogeneic antigen were measured. EAT onset, development and recovery correlate with the presence of two subsets of A‐Ab only in susceptible strains of mice. First, with the presence of anti‐Tg A‐Ab to one determinant borne by the linear 5‐10‐kDa Tg tryptic fragment, and second with the presence of anti‐idiotypic A‐Ab specific for the monoclonal anti‐Tg A‐Ab (3B8G9) paratope which binds to Tg determinant inducing EAT. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1535 / 1539

页数：5

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