FUNCTIONAL-ROLE OF ASPARTIC ACID-27 IN DIHYDROFOLATE-REDUCTASE REVEALED BY MUTAGENESIS

被引:233
作者
HOWELL, EE [1 ]
VILLAFRANCA, JE [1 ]
WARREN, MS [1 ]
OATLEY, SJ [1 ]
KRAUT, J [1 ]
机构
[1] UNIV CALIF SAN DIEGO,DEPT CHEM,LA JOLLA,CA 92093
关键词
D O I
10.1126/science.3511529
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1123 / 1128
页数:6
相关论文
共 42 条
[1]   PURIFICATION AND PROPERTIES OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].
BACCANARI, D ;
PHILLIPS, A ;
SMITH, S ;
SINSKI, D ;
BURCHALL, J .
BIOCHEMISTRY, 1975, 14 (24) :5267-5273
[2]  
BACCANARI DP, 1981, J BIOL CHEM, V256, P1738
[3]  
Blakley R. L., 1984, FOLATES PTERINES, P191
[4]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[5]   KINETICS OF SUBSTRATE, COENZYME, AND INHIBITOR BINDING TO ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].
CAYLEY, PJ ;
DUNN, SMJ ;
KING, RW .
BIOCHEMISTRY, 1981, 20 (04) :874-879
[6]  
CHARLTON PA, 1979, J CHEM SOC CHEM COMM, V20, P922
[7]   SITE-SPECIFIC MUTAGENESIS OF DIHYDROFOLATE-REDUCTASE FROM ESCHERICHIA-COLI [J].
CHEN, JT ;
MAYER, RJ ;
FIERKE, CA ;
BENKOVIC, SJ .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1985, 29 (02) :73-82
[8]   C-13 NUCLEAR MAGNETIC-RESONANCE STUDY OF PROTONATION OF METHOTREXATE AND AMINOPTERIN BOUND TO DIHYDROFOLATE-REDUCTASE [J].
COCCO, L ;
GROFF, JP ;
TEMPLE, C ;
MONTGOMERY, JA ;
LONDON, RE ;
MATWIYOFF, NA ;
BLAKLEY, RL .
BIOCHEMISTRY, 1981, 20 (14) :3972-3978
[9]   PROTONATED STATE OF METHOTREXATE, TRIMETHOPRIM, AND PYRIMETHAMINE BOUND TO DIHYDROFOLATE-REDUCTASE [J].
COCCO, L ;
ROTH, B ;
TEMPLE, C ;
MONTGOMERY, JA ;
LONDON, RE ;
BLAKLEY, RL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 226 (02) :567-577
[10]   REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY [J].
CRAIK, CS ;
LARGMAN, C ;
FLETCHER, T ;
ROCZNIAK, S ;
BARR, PJ ;
FLETTERICK, R ;
RUTTER, WJ .
SCIENCE, 1985, 228 (4697) :291-297