NON-NMDA RECEPTOR MEDIATES CYTOPLASMIC CA-2+ ELEVATION IN CULTURED HIPPOCAMPAL-NEURONS

被引：59

作者：

OGURA, A

AKITA, K

KUDO, Y

机构：

[1] Department of Neuroscience, Mitsubishi Kasei Institute of Life Sciences, Tokyo

来源：

NEUROSCIENCE RESEARCH | 1990年 / 9卷 / 02期

关键词：

Cultured neurone; Cytoplasmic Ca[!sup]2+[!/sup; Excitatory amino acid receptor; Fura-2; Hippocampus; Kainate; N-Methyl-d-aspartate; Quisqualate;

D O I：

10.1016/0168-0102(90)90026-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microscopic fluorometry of cultured rat hippocampal neurones revealed that the intracellular concentration of Ca2+ ([Ca2+]i) rises in response to the activation of excitatory amino acid receptor (EAA-R), which included not only N-methyl-d-aspartate subspecies but also kainate and quisqualate subspecies of EAA-R. Each EAA-R mediated [Ca2+]i rise consisted of the components dependent on and independent of the activity of the voltage-dependent Ca2+ channel. The receptor-mediated voltage-independent [Ca2+]i rise may be related to the modulation of synaptic transmission efficacy. © 1990.

引用

页码：103 / 113

页数：11

共 26 条

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