DIMETHYL-PHOSPHATE HYDROLYSIS AT NEUTRAL PH

被引：97

作者：

KIM, JH ^{[1
]}

CHIN, J ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 25期

关键词：

D O I：

10.1021/ja00051a011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[(cyclen)Co(OH2)2]3+ (1) hydrolyzes dimethyl phosphate with a second-order rate constant of 6.2 x 10(-7) M-1 s-1 at 60-degrees-C, pD 6.3 (cyclen: 1,4,7,10-tetraazacyclododecane). In contrast, [(tetren)Co(OH2)]3+ (2) does not hydrolyze the diester to any observable extent, even when the reaction solution is heated to 100-degrees-C for 1 month (tetren: tetraethylenepentamine). The mechanism for 1-promoted hydrolysis of dimethyl phosphate involves joint Lewis acid activation and metal hydroxide activation.

引用

页码：9792 / 9795

页数：4

共 26 条

[1] EFFECTS OF METAL-IONS, INCLUDING MG2+ AND LANTHANIDES, ON THE CLEAVAGE OF RIBONUCLEOTIDES AND RNA MODEL COMPOUNDS
BRESLOW, R
HUANG, DL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) : 4080 - 4083
[2] THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES
CECH, TR
[J]. SCIENCE, 1987, 236 (4808) : 1532 - 1539
[3] CO(III) COMPLEX PROMOTED HYDROLYSIS OF PHOSPHATE DIESTERS - COMPARISON IN REACTIVITY OF RIGID CIS-DIAQUOTETRAAZACOBALT(III) COMPLEXES
CHIN, J
BANASZCZYK, M
JUBIAN, V
ZOU, X
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (01) : 186 - 190
[4] DEVELOPING ARTIFICIAL HYDROLYTIC METALLOENZYMES BY A UNIFIED MECHANISTIC APPROACH
CHIN, J
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (05) : 145 - 152
[5] CATALYTIC HYDROLYSIS OF CAMP
CHIN, J
ZOU, X
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1987, 65 (08) : 1882 - 1884
[6] HIGHLY EFFICIENT HYDROLYTIC CLEAVAGE OF ADENOSINE-MONOPHOSPHATE RESULTING IN A BINUCLEAR CO(III) COMPLEX WITH A NOVEL DOUBLY BIDENTATE MU-4-PHOSPHATO BRIDGE
CHIN, J
BANASZCZYK, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (11) : 4103 - 4105
[7] METAL ION ACTIVATION OF PHOSPHATE TRANSFER BY BIDENTATE COORDINATION
FARRELL, FJ
KJELLSTROM, WA
SPIRO, TG
[J]. SCIENCE, 1969, 164 (3877) : 320 - +
[8] GELT JA, 1975, J BIOL CHEM, V250, P5059
[9] EFFECT OF THE ACYL SUBSTITUENT ON THE EQUILIBRIUM-CONSTANT FOR HYDRATION OF ESTERS
GUTHRIE, JP
CULLIMORE, PA
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (13): : 1281 - 1294
[10] HYDRATION AND DEHYDRATION OF PHOSPHORIC-ACID DERIVATIVES - FREE-ENERGIES OF FORMATION OF PENTACOORDINATE INTERMEDIATES FOR PHOSPHATE ESTER HYDROLYSIS AND OF MONOMERIC METAPHOSPHATE
GUTHRIE, JP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (12) : 3991 - 4001

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