EFFECT OF BETA-LACTAMASE INHIBITORS ON THE ACTIVITIES OF VARIOUS BETA-LACTAM AGENTS AGAINST ANAEROBIC-BACTERIA

被引：33

作者：

WEXLER, HM

MOLITORIS, E

FINEGOLD, SM

机构：

[1] VET ADM WADSWORTH MED CTR,MED SERV,LOS ANGELES,CA 90073

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 06期

关键词：

D O I：

10.1128/AAC.35.6.1219

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of several new beta-lactam-beta-lactamase inhibitor combinations (piperacillin plus tazobactam, ceftizoxime and cefonicid with sulbactam and clavulanic acid, and ampicillin plus 8-mu-g of sulbactam per ml) were tested with anaerobic bacteria and compared with known beta-lactam-beta-lactamase inhibitor combinations and other potent antianaerobe agents. All the combinations tested (except for the cefonicid-inhibitor combinations) were active against almost all strains of the Bacteroides fragilis group. This report indicates that beta-lactamase inhibitors may improve the activity of beta-lactam agents with marginal activity against the B. fragilis group.

引用

页码：1219 / 1224

页数：6

共 16 条

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