THE ROLE OF TUMOR-NECROSIS-FACTOR IN SEPSIS

被引:104
作者
SPOONER, CE [1 ]
MARKOWITZ, NP [1 ]
SARAVOLATZ, LD [1 ]
机构
[1] UNIV MICHIGAN,SCH MED,ANN ARBOR,MI 48109
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 62卷 / 01期
关键词
D O I
10.1016/0090-1229(92)90036-N
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There is an increasing incidence of sepsis among hospitalized patients. Also, high mortality associated with sepsis and septic shock persists despite appropriate antibiotic therapy. Recent investigations have demonstrated that bacterial antigens stimulate a cascade of cellular mediators or cytokine release. In sepsis and septic shock the response of these cytokines often exceeds natural downregulation and leads to multisystem organ failure and even death in an unacceptably high number of patients. Many investigative studies have shown that tumor necrosis factor (TNF) is the prime mediator of the inflammatory response seen in sepsis and septic shock. Sepsis management in the future will include immune modulating therapy directed against the deleterious effects of cytokines, specifically TNF. This article reviews the current problem of sepsis and the evidence to support the role of TNF in sepsis. Also, recent studies employing monoclonal antibodies against TNF as well as considerations for future studies are discussed. © 1992.
引用
收藏
页码:S11 / S17
页数:7
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