COMPLEMENT C1 INHIBITOR IS PRODUCED BY BRAIN-TISSUE AND IS CLEAVED IN ALZHEIMER-DISEASE

被引:71
作者
WALKER, DG
YASUHARA, O
PATSTON, PA
MCGEER, EG
MCGEER, PL
机构
[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER,BC V6T 1Z3,CANADA
[2] VANDERBILT UNIV,DEPT MED,NASHVILLE,TN
关键词
C1; INHIBITOR; ALZHEIMER DISEASE; DYSTROPHIC NEURITE; SUICIDE REACTION;
D O I
10.1016/0006-8993(95)00041-N
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
CI inhibitor was identified in human brain tissue by Western blotting and by immunohistochemistry using multiple antibodies to the native protein. The presence of C1 inhibitor mRNA was identified by reverse transcriptase-polymerase chain reaction analysis of brain mRNA extracts. The mRNA was also detected in cultured postmortem human microglia and in the IMR-32 human neuroblastoma cell line. Immunohistochemically, the native protein was detected in residual serum of capillaries and pyramidal neurons of both control and Alzheimer disease cases, as well as in occasional senile plaques of Alzheimer tissue. The reacted protein was detected on dystrophic neurites and neuropil threads in Alzheimer tissue by 4C3 monoclonal antibody, which recognizes a neoepitope following suicide inhibition. These data indicate that C1 inhibitor, a regulatory molecule controlling multiple inflammatory proteolytic cascades, is produced in normal brain. In Alzheimer disease, C1 inhibitor undergoes a prominent reaction in abnormal neuronal processes, such as dystrophic neurites and neuropil threads.
引用
收藏
页码:75 / 82
页数:8
相关论文
共 31 条
  • [1] ASSOCIATION OF AMYLOID-P COMPONENT WITH COMPLEMENT PROTEINS IN NEUROLOGICALLY DISEASED BRAIN-TISSUE
    AKIYAMA, H
    YAMADA, T
    KAWAMATA, T
    MCGEER, PL
    [J]. BRAIN RESEARCH, 1991, 548 (1-2) : 349 - 352
  • [2] BRAIN MICROGLIA CONSTITUTIVELY EXPRESS BETA-2 INTEGRINS
    AKIYAMA, H
    MCGEER, PL
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1990, 30 (01) : 81 - 93
  • [3] THROMBIN ACCUMULATION IN BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE
    AKIYAMA, H
    IKEDA, K
    KONDO, H
    MCGEER, PL
    [J]. NEUROSCIENCE LETTERS, 1992, 146 (02) : 152 - 154
  • [4] HUMAN C1BAR INHIBITOR - PRIMARY STRUCTURE, CDNA CLONING, AND CHROMOSOMAL LOCALIZATION
    BOCK, SC
    SKRIVER, K
    NIELSEN, E
    THOGERSEN, HC
    WIMAN, B
    DONALDSON, VH
    EDDY, RL
    MARRINAN, J
    RADZIEJEWSKA, E
    HUBER, R
    SHOWS, TB
    MAGNUSSON, S
    [J]. BIOCHEMISTRY, 1986, 25 (15) : 4292 - 4301
  • [5] GENOMIC AND CDNA CLONING OF THE HUMAN C1 INHIBITOR - INTRON-EXON JUNCTIONS AND COMPARISON WITH OTHER SERPINS
    CARTER, PE
    DUNBAR, B
    FOTHERGILL, JE
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 173 (01): : 163 - 169
  • [6] COMPLETE NUCLEOTIDE-SEQUENCE OF THE GENE FOR HUMAN C1 INHIBITOR WITH AN UNUSUALLY HIGH-DENSITY OF ALU ELEMENTS
    CARTER, PE
    DUPONCHEL, C
    TOSI, M
    FOTHERGILL, JE
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 197 (02): : 301 - 308
  • [7] A COMMON NEOEPITOPE IS CREATED WHEN THE REACTIVE CENTER OF C1-INHIBITOR IS CLEAVED BY PLASMA KALLIKREIN, ACTIVATED FACTOR-XII FRAGMENT, C1 ESTERASE, OR NEUTROPHIL ELASTASE
    DEAGOSTINI, A
    PATSTON, PA
    MAROTTOLI, V
    CARREL, S
    HARPEL, PC
    SCHAPIRA, M
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) : 700 - 705
  • [8] PROTHROMBIN MESSENGER-RNA IS EXPRESSED BY CELLS OF THE NERVOUS-SYSTEM
    DIHANICH, M
    KASER, M
    REINHARD, E
    CUNNINGHAM, D
    MONARD, D
    [J]. NEURON, 1991, 6 (04) : 575 - 581
  • [9] IMMUNODETECTION OF THE AMYLOID-P COMPONENT IN ALZHEIMERS-DISEASE
    DUONG, T
    POMMIER, EC
    SCHEIBEL, AB
    [J]. ACTA NEUROPATHOLOGICA, 1989, 78 (04) : 429 - 437
  • [10] DETECTION OF COMPLEMENT PROTEIN MESSENGER-RNA IN HUMAN ASTROCYTES BY THE POLYMERASE CHAIN-REACTION
    GORDON, DL
    AVERY, VM
    ADRIAN, DL
    SADLON, TA
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 1992, 45 (03) : 191 - 197