ANTIEPILEPTIC DRUG MECHANISMS OF ACTION

被引:364
作者
MACDONALD, RL
KELLY, KM
机构
[1] UNIV MICHIGAN,MED CTR,DEPT NEUROL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,MED CTR,DEPT PHYSIOL,ANN ARBOR,MI 48109
关键词
ANTICONVULSANTS; NEUROPHARMACOLOGY; BENZODIAZEPINES; BARBITURATES; PHENYTOIN; CARBAMAZEPINE; ETHOSUXIMIDE; TRIMETHADIONE; VALPROATE; GABAPENTIN; LAMOTRIGINE; VIGABATRIN;
D O I
10.1111/j.1528-1157.1995.tb05996.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed before 1980 appear to act on sodium channels, gamma-aminobutyric acid type A (GABA(A)) receptors, or calcium channels. Benzodiazepines and barbiturates enhance GABA(A) receptor-mediated inhibition. Phenytoin (PHT), carbamazepine (CBZ), and possibly valproate (VPA) decrease high-frequency repetitive firing of action potentials by enhancing sodium-channel inactivation. Ethosuximide (ESM) and VPA reduce a low threshold (T-type) calcium-channel current. The mechanisms of action of the new AEDs are not fully established. Gabapentin (GBP) binds to a high-affinity site on neuronal membranes in a restricted regional distribution of the central nervous system. This binding site may be related to a possible active transport process of GBP into neurons; however, this has not been proven, and the mechanism of action of GBP remains uncertain. Lamotrigine (LTG) decreases sustained high-frequency repetitive firing of voltage-dependent sodium action potentials that may result in a preferential decreased release of presynaptic glutamate. The mechanism of action of oxcarbazepine (OCBZ) is not known; however, its similarity in structure and clinical efficacy to CBZ suggests that its mechanism of action may involve inhibition of sustained high-frequency repetitive firing of voltage-dependent sodium action potentials. Vigabatrin (VGB) irreversibly inhibits GABA transaminase, the enzyme that degrades GABA, thereby producing greater available pools of presynaptic GABA for release in central synapses. Increased activity of GABA at postsynaptic receptors may underlie the clinical efficacy of VGB.
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页码:S2 / S12
页数:11
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