FMRF-NH2-LIKE MAMMALIAN OCTAPEPTIDE - POSSIBLE ROLE IN OPIATE DEPENDENCE AND ABSTINENCE

被引：148

作者：

MALIN, DH ^{[1
]}

LAKE, JR ^{[1
]}

HAMMOND, MV ^{[1
]}

FOWLER, DE ^{[1
]}

ROGILLIO, RB ^{[1
]}

BROWN, SL ^{[1
]}

SIMS, JL ^{[1
]}

LEECRAFT, BM ^{[1
]}

YANG, HYT ^{[1
]}

机构：

[1] NIMH, NEUROSCI CTR ST ELIZABETH, BIOCHEM GENET LAB, WASHINGTON, DC 20032 USA

来源：

PEPTIDES | 1990年 / 11卷 / 05期

关键词：

Abstinence syndrome; Cerebrospinal fluid; FMRF-NH[!sub]2[!/sub; Morphine; Naloxone; Neuropeptides; Opiate antagonists; Opiate dependence; Opiates;

D O I：

10.1016/0196-9781(90)90018-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yang et al. have isolated from bovine brain an octapeptide, FLFQPQRF-NH2 (F-8-F-NH2), with certain antiopiate properties. Malin et al. previously found that ICV injection of this peptide could precipitate an opiate abstinence syndrome in dependent rats. RIA revealed significantly higher levels of F-8-F-NH2 immunoreactivity in CSF withdrawn from the cisterna magna of morphine-dependent rats as opposed to CSF withdrawn from sham-implanted controls. ICV infusion of IgG from antiserum against F-8-F-NH2 significantly reduced the number of abstinence signs subsequently precipitated by naloxone in morphine-dependent rats. © 1990.

引用

页码：969 / 972

页数：4

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