THE SUBTYPES OF THE MOUSE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR ARE EXPRESSED IN A TISSUE-SPECIFIC AND DEVELOPMENTALLY SPECIFIC MANNER

被引：242

作者：

NAKAGAWA, T ^{[1
]}

OKANO, H ^{[1
]}

FURUICHI, T ^{[1
]}

ARUGA, J ^{[1
]}

MIKOSHIBA, K ^{[1
]}

机构：

[1] NATL INST BASIC BIOL,DIV BEHAV & NEUROBIOL,OKAZAKI,AICHI 444,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 14期

关键词：

LIGAND-GATED CALCIUM CHANNEL; ALTERNATIVE SPLICING;

D O I：

10.1073/pnas.88.14.6244

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Additional subtypes of the inositol 1,4,5-trisphosphate (InsP3) receptor are expressed in a tissue-specific and developmentally specific manner. They differ from the InsP3 receptor structure previously reported in two small variably spliced segments. One segment (SI) is located within the InsP3 binding site, whereas another segment (SII) is located near putative sites for phosphorylation and ATP binding to modulate InsP3 action on Ca2+ flux. Therefore, we speculate that selective use of InsP3 receptor subtypes permits a tissue-specific and developmentally specific expression of functionally distinct channels.

引用

页码：6244 / 6248

页数：5

共 33 条

[1] POSTNATAL-DEVELOPMENT OF CEREBELLAR CORTEX IN RAT .2. PHASES IN MATURATION OF PURKINJE-CELLS AND OF MOLECULAR LAYER
ALTMAN, J
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1972, 145 (04) : 399 - +
[2] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS
AMARA, SG
JONAS, V
ROSENFELD, MG
ONG, ES
EVANS, RM
[J]. NATURE, 1982, 298 (5871) : 240 - 244
[3] INOSITOL PHOSPHATES AND CELL SIGNALING
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1989, 341 (6239) : 197 - 205
[4] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1984, 312 (5992) : 315 - 321
[5] ALTERNATIVE SPLICING - A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES
BREITBART, RE
ANDREADIS, A
NADALGINARD, B
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 467 - 495
[6] ISOLATION AND CHARACTERIZATION OF THE INOSITOL TRISPHOSPHATE RECEPTOR FROM SMOOTH-MUSCLE
CHADWICK, CC
SAITO, A
FLEISCHER, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2132 - 2136
[7] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE
CHIRGWIN, JM
PRZYBYLA, AE
MACDONALD, RJ
RUTTER, WJ
[J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299
[8] INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - DISTINCT NEURONAL AND NONNEURONAL FORMS DERIVED BY ALTERNATIVE SPLICING DIFFER IN PHOSPHORYLATION
DANOFF, SK
FERRIS, CD
DONATH, C
FISCHER, GA
MUNEMITSU, S
ULLRICH, A
SNYDER, SH
ROSS, CA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) : 2951 - 2955
[9] CALCIUM FLUX MEDIATED BY PURIFIED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RECONSTITUTED LIPID VESICLES IS ALLOSTERICALLY REGULATED BY ADENINE-NUCLEOTIDES
FERRIS, CD
HUGANIR, RL
SNYDER, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2147 - 2151
[10] PURIFIED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR MEDIATES CALCIUM FLUX IN RECONSTITUTED LIPID VESICLES
FERRIS, CD
HUGANIR, RL
SUPATTAPONE, S
SNYDER, SH
[J]. NATURE, 1989, 342 (6245) : 87 - 89

← 1 2 3 4 →