THE PATHOGENETIC ASPECTS OF SPONDYLOARTHROPATHIES FROM THE POINT-OF-VIEW OF HLA-B27

被引：18

作者：

KELLNER, H ^{[1
]}

YU, D ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CTR REHABIL,DIV RHEUMATOL,1000 VET AVE,LOS ANGELES,CA 90024

来源：

RHEUMATOLOGY INTERNATIONAL | 1992年 / 12卷 / 04期

关键词：

SPONDYLOARTHROPATHIES; ANKYLOSING SPONDYLITIS; HLA CLASS-I ANTIGENS; HLA-B27; SUBTYPES; ARTHRITOGENIC PEPTIDES;

D O I：

10.1007/BF00274931

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.

引用

页码：121 / 127

页数：7

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