STUDIES ON THE ISOTETRACENONE ANTIBIOTICS .4. HATOMARUBIGIN-A, HATOMARUBIGIN-B, HATOMARUBIGIN-C AND HATOMARUBIGIN-D, NEW ISOTETRACENONE ANTIBIOTICS EFFECTIVE AGAINST MULTIDRUG-RESISTANT TUMOR-CELLS

被引:28
作者
HAYAKAWA, Y [1 ]
HA, SC [1 ]
KIM, YJ [1 ]
FURIHATA, K [1 ]
SETO, H [1 ]
机构
[1] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.7164/antibiotics.44.1179
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A complex of new isotetracenone group antibiotics was isolated from the cultured broth of Streptomyces sp. 2238-SVT4. It consisted of four related compounds, designated hatomarubigins A, B, C and D, whose structures were elucidated by NMR spectral analysis including a variety of 2D techniques. They enhanced the cytotoxicity of colchicine against multidrug-resistant tumor cells.
引用
收藏
页码:1179 / 1188
页数:10
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