STUDIES ON THE ISOTETRACENONE ANTIBIOTICS .4. HATOMARUBIGIN-A, HATOMARUBIGIN-B, HATOMARUBIGIN-C AND HATOMARUBIGIN-D, NEW ISOTETRACENONE ANTIBIOTICS EFFECTIVE AGAINST MULTIDRUG-RESISTANT TUMOR-CELLS

被引：28

作者：

HAYAKAWA, Y ^{[1
]}

HA, SC ^{[1
]}

KIM, YJ ^{[1
]}

FURIHATA, K ^{[1
]}

SETO, H ^{[1
]}

机构：

[1] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 11期

关键词：

D O I：

10.7164/antibiotics.44.1179

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A complex of new isotetracenone group antibiotics was isolated from the cultured broth of Streptomyces sp. 2238-SVT4. It consisted of four related compounds, designated hatomarubigins A, B, C and D, whose structures were elucidated by NMR spectral analysis including a variety of 2D techniques. They enhanced the cytotoxicity of colchicine against multidrug-resistant tumor cells.

引用

页码：1179 / 1188

页数：10

共 10 条

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