IGG(2) DEFICIENCY IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS INFECTIONS AFTER ESOPHAGEAL SURGERY

被引：4

作者：

SAITO, T

KINOSHITA, T

SHIGEMITSU, Y

KATSUTA, T

SHIMODA, K

KOBAYASHI, M

机构：

[1] First Department of Surgery, Oita Medical University, Oita, 879-55, Hasamamachi

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 02期

关键词：

IGG(2) DEFICIENCY; MRSA; ESOPHAGEAL CANCER;

D O I：

10.1007/BF02473408

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We previously reported the selective development of methicillin-resistant Staphylococcus aureus (MRSA) infections following esophageal surgery in patients with a reduced ability to produce anti-pneumococcal polysaccharide (PPS) IgG. Since the response to the PPS vaccine is correlated to the serum IgG(2) levels, we measured IgG(2) in the same series of esophageal cancer patients. IgG subclasses were determined in 21 patients, 8 of whom developed MRSA infections. IgG(2) was thus found to be significantly lower (P < 0.01) in patients with MRSA infections (453 mg/dl) than in those without such infections (666 mg/dl). There was also a significantly positive correlation (r = 0.61) between anti-PPS IgG and serum IgG(2). Therefore, the preoperative measurement of serum IgG(2) is considered to be useful in detecting patients who are at risk for developing an MRSA infection after esophageal surgery.

引用

页码：187 / 188

页数：2

共 6 条

[1]

Saito T., Kinoshita T., Shigemitsu Y., Katsuta T., Shimoda K., Kobayashi M., Methicillin-resistant Staphylococcus aureus infections following esophageal surgery in patients with impaired defense mechanisms, Surgery Today (Jpn J Surg), 23, pp. 947-953, (1993)

[2]

Schur P.H., Borel H., Gelfand E.W., Alper C.A., Rosen F.S., Selective gamma-G globulin deficiencies in patients with recurrent pyogenic infections, N Engl J Med, 283, pp. 631-634, (1970)

[3]

Oxelius V., Chronic infections in a family with hereditary deficiency of IgG2 and IgG4, Clin Exp Immunol, 17, pp. 19-27, (1974)

[4]

Hammarstrom L., Granstrom M., Oxelius V., Persson M.A.A., Smith C.L.E., IgG subclass distribution of antibodies against S. aureus teichoic acid and toxin in normal and immunodeficient donors, Clin Exp Immunol, 55, (1984)

[5]

Siber G.R., Schur P.H., Aisenberg A.C., Weitzman S.A., Schiffman G., Correlation between serum IgG2 concentrations and the antibody response to bacterial polysaccharide antigens, N Engl J Med, 303, pp. 178-182, (1980)

[6]

Bird P., Calvert J.E., Lowe J., Duggan-Keen M., Forouhi N.G., Seppala I., Ling N.R., ELISA measurement of IgG subclass production in culture supernatants using monoclonal antibodies, J Immunol Method, 104, pp. 149-158, (1987)

← 1 →