INHIBITORY EFFECT OF ETHANOLAMINE PLASMALOGEN ON IRON-DEPENDENT AND COPPER-DEPENDENT LIPID-PEROXIDATION

被引：49

作者：

ZOMMARA, M ^{[1
]}

TACHIBANA, N ^{[1
]}

MITSUI, K ^{[1
]}

NAKATANI, N ^{[1
]}

SAKONO, M ^{[1
]}

IKEDA, I ^{[1
]}

IMAIZUMI, K ^{[1
]}

机构：

[1] KYUSHU UNIV,SCH AGR 4609,DEPT FOOD SCI & TECHNOL,NUTR LAB,FUKUOKA 812,JAPAN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 18卷 / 03期

关键词：

PLASMALOGEN; TRANSITION METALS; LIPID PEROXIDATION; FREE RADICALS;

D O I：

10.1016/0891-5849(94)00155-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of ethanolamine plasmalogen (EtnPm) on lipid peroxidation was investigated in liposomal suspension of egg yolk phosphatidylcholine. EtnPm inhibited iron- and copper-dependent peroxidation in the presence of preformed hydroperoxides, although it was not effective for radical initiator mediated lipid peroxidation. EtnPm resulted in complete binding of iron to liposomal lipids, suggesting that EtnPm exerts its inhibitory effect on lipid peroxidation through inhibiting preformed peroxide decomposition by trapping transition metal ions.

引用

页码：599 / 602

页数：4

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