STRUCTURAL COMPARISON OF NK2 RECEPTOR AGONISTS AND ANTAGONISTS

被引：7

作者：

GIOLITTI, A

MAGGI, CA

机构：

[1] Menarini Research, Florence, I-50131

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 1994年 / 8卷 / 03期

关键词：

TACHYKININS; NK-2; MEN-10627; BINDING; AGONIST; ANTAGONIST;

D O I：

10.1007/BF00126750

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conformational space of two NK2 receptor agonists and a new potent antagonist has been sampled by the simulated annealing technique. Low-energy conformers were obtained, which were compared with respect to their key residues, namely phenylalanine, leucine and methionine. The hypothesis is that they share part of the binding site on the receptor.

引用

页码：341 / 344

页数：4

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