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CLOSTRIDIAL ADP-RIBOSYLATING TOXINS - EFFECTS ON ATP AND GTP-BINDING PROTEINS

被引：46
作者：
AKTORIES, K
机构：
[1] Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg-Saar
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1994年 / 138卷 / 1-2期
关键词：
ADP-RIBOSYLATION; ACTIN; CLOSTRIDIUM BOTULINUM C2 TOXIN; CLOSTRIDIUM PERFRINGENS TOXIN; CLOSTRIDIUM BOTULINUM C3 EXOENZYME; CLOSTRIDIUM LIMOSUM EXOENZYME; GELSOLIN; LOW-MOLECULAR-MASS GTP-BINDING PROTEINS; RHO;
D O I：
10.1007/BF00928459
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要：
The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years. Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization. Clostridium botulinum exoenzyme C3 and Clostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of the actin cytoskeleton. ADP-ribosylation inactivates the regulatory Rho proteins and disturbs the organization of the actin cytoskeleton.
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页码：167 / 176
页数：10
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