DIFFERENTIATION OF A HUMAN MONOCYTE-LIKE CELL-LINE BY (2'-5') OLIGOISOADENYLATE

被引：17

作者：

SCHMIDT, A ^{[1
]}

HATTORI, T ^{[1
]}

HOFFMAN, T ^{[1
]}

机构：

[1] NCI, BIOL THERAPEUT BRANCH, FREDERICK, MD 21701 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1984年 / 150卷 / 02期

关键词：

D O I：

10.1016/0014-4827(84)90571-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of a human monocyte-like cell line (U-937) by (2''-5'')ApApA, the 5'' dephosphorylated product of (2''-5'')oligo-isoadenylate [oligo(A)] synthetase, an interferon-induced enzyme, was able to induce differentiation, mimicking the effect of interferon treatment. Treatment of U-937 cells with (2''-5'')ApApA resulted in morphologic changes, new (monocyte-associated) membrane antigen expression, and acquisition of the capacity to mediate antibody-dependent cellular cytotoxicity (ADCC). (2''-5'')ApA and (3''-5'')ApApA were without effect. A myeloid cell line (HL-60) which differentiates in response to other agents, but not to .alpha.-interferon, was not able to differentiate in response to (2''-5'')ApApA, despite the ability of interferon to induce (2''-5'')oligo (A) synthetase.

引用

页码：292 / 297

页数：6

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