IMMUNOGENICITY OF YEAST-DERIVED HEPATITIS-B VACCINE FROM 2 DIFFERENT PRODUCERS

被引：24

作者：

DAHLHANSEN, E

SIEBKE, JC

FROLAND, SS

DEGRE, M

机构：

[1] NATL HOSP NORWAY,DEPT INTERNAL MED,N-0027 OSLO 1,NORWAY

[2] NATL HOSP NORWAY,INST BACTERIOL,N-0027 OSLO 1,NORWAY

[3] NATL INST PUBL HLTH,DEPT VIROL,N-0462 OSLO 4,NORWAY

来源：

EPIDEMIOLOGY AND INFECTION | 1990年 / 104卷 / 01期

关键词：

D O I：

10.1017/S0950268800054625

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The immunogenicity and reactogenicity of two preparations of yeast-derived hepatitis B vaccines were compared in healthy adult populations. The two groups were vaccinated in parallel, but they were not matched for age and sex. All subjects seroconverted, and 9 months after the first vaccine dose, all had anti HBs titres of at least 10 IU/1. The anti-HBs titres were higher in the group of subjects given 20 fig vaccine antigen made by Smith Kline & RIT (GMT 2943 at 9 months) compared to those who received 10µg of vaccine made by Merck, Sharp & Dohme (GMT 729 at 9 months). Adverse effects were recorded in 32-0 and 44-7% of the participants, but these were limited to minor local and general reactions. In the present study both preparations were safe and efficient. © 1990, Cambridge University Press. All rights reserved.

引用

页码：143 / 149

页数：7

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