SERUM GRANULOCYTE COLONY-STIMULATING FACTOR LEVELS IN CHRONIC NEUTROPENIA OF INFANCY

Eight infants with chronic neutropenia ranging in age from 1 to 13 months were studied for serum granulocyte colony-stimulating factor (G-CSF) levels. Serum G-CSF levels were elevated, especially when peripheral blood absolute neutrophil counts (ANC) were under 500/μl in seven patients with autoimmune neutropenia. On the other hand, in a patient with congenital agranulocytosis (Kostmann type), G-CSF levels were below the sensitivity of the assay (<50 pg/ml) despite severe neutropenia (<100/μl). © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.