REDUCTION OF CYTOCHROME-C BY FRAGMENTS OF HEAT-SHOCK PROTEIN-70

被引：12

作者：

SIMPKINS, CO ^{[1
]}

FOGARTY, KW ^{[1
]}

NHAMBURO, P ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21201

来源：

LIFE SCIENCES | 1993年 / 52卷 / 18期

关键词：

D O I：

10.1016/0024-3205(93)90110-O

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Using absorption spectroscopy, we have found that two highly conserved fragments of heat shock protein 70 reduce cytochrome c. The fragments are SCV and YSCVGVF. YSCVGVF was more potent than SCV at low concentrations (10(-6) - 10(-4)M). At high concentrations (5x10(-4) - 10(-3)M) SCV was more potent than YSCVGVF. Reduction of CC by YSCVGVF was reversed by cytochrome c oxidase. These findings show that heat shock protein 70 and/or small intracellular peptides could carry electrons to cytochromes.

引用

页码：1487 / 1492

页数：6

共 12 条

[1]

ANG AD, 1991, J BIOL CHEM, V266, P24233

[2] REDUCTION OF HORSE HEART FERRICYTOCHROME-C BY GLUTATHIONE - EVIDENCE FOR 2 DIFFERENT CONFORMATIONAL FORMS OF FERRICYTOCHROME-C IN NEUTRAL AND SLIGHTLY ALKALINE-SOLUTIONS [J].

KUJUNDZIC, N ;

EVERSE, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 82 (04) :1211-1216

[3] DEREPRESSION OF FERRITIN MESSENGER-RNA TRANSLATION BY HEMIN INVITRO [J].

LIN, JJ ;

DANIELSMCQUEEN, S ;

PATINO, MM ;

GAFFIELD, L ;

WALDEN, WE ;

THACH, RE .

SCIENCE, 1990, 247 (4938) :74-77

[4]

LINQUIST S, 1986, ANN REV BIOCH, V55, P1157

[5] PURIFICATION AND PROPERTIES OF HEME-DEFICIENT HEPATIC SOLUBLE GUANYLATE-CYCLASE - EFFECTS OF HEME AND OTHER FACTORS ON ENZYME ACTIVATION BY NO, NO-HEME, AND PROTOPORPHYRIN-IX [J].

OHLSTEIN, EH ;

WOOD, KS ;

IGNARRO, LJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1982, 218 (01) :187-198

[6]

SAKURAI H, 1980, CHEM PHARM BULL, V28, P3437

[7] THE REACTIVITY OF CYTOCHROME-C WITH SOFT LIGANDS [J].

SCHEJTER, A ;

PLOTKIN, B ;

VIG, I .

FEBS LETTERS, 1991, 280 (02) :199-201

[8]

SIMPKINS C, 1990, J NATL MED ASSOC, V82, P113

[9] INTERACTION BETWEEN CYTOCHROME-C AND DIPEPTIDES AND TRIPEPTIDES [J].

SIMPKINS, C ;

WILLIAMSON, G ;

MOORE, C .

LIFE SCIENCES, 1991, 48 (06) :523-530

[10]

SIMPKINS CO, UNPUB

← 1 2 →