CHARACTERISTICS AND DISTRIBUTION OF BETA-THALASSEMIA HAPLOTYPES IN SOUTH CHINA

被引：40

作者：

CHAN, V

CHAN, TK

CHENG, MY

LEUNG, NK

KAN, YW

TODD, D

机构：

[1] UNIV HONG KONG, QUEEN MARY HOSP, DEPT MED, HONG KONG, HONG KONG

[2] UNIV HONG KONG, QUEEN MARY HOSP, DEPT PAEDIAT, HONG KONG, HONG KONG

[3] UNIV CALIF SAN FRANCISCO, SCH MED, HOWARD HUGHES MED INST, DEPT MED, SAN FRANCISCO, CA 94143 USA

[4] PRINCESS MARGARET HOSP, PAEDIAT UNIT A, HONG KONG, HONG KONG

来源：

HUMAN GENETICS | 1986年 / 73卷 / 01期

关键词：

D O I：

10.1007/BF00292658

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Eleven restriction site polymorphisms in the .beta.-globin gene cluster were determined in 48 Chinese with homozygous .beta.-thalassemia and their parents. Seven haplotypes were identified as associated with the .beta.thal chromosome and 25 with the .beta.A chromosome. The distribution at the various .beta.thal haplotypes in different regions of South China was mapped and discussed in relation to prenatal diagnosis and migration of the Chinese people.

引用

页码：23 / 26

页数：4

共 19 条

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