AN ENZYMATIC MECHANISM FOR POTASSIUM CHANNEL STIMULATION THROUGH PERTUSSIS-TOXIN-SENSITIVE G-PROTEINS

被引：60

作者：

ARMSTRONG, DL

WHITE, RE

机构：

[1] Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 10期

关键词：

D O I：

10.1016/0166-2236(92)90192-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many neurotransmitters inhibit secretion from electrically excitable cells by activating pertussis-toxin-sensitive G proteins that modulate voltage-gated ion channels. Recent electrophysiological studies of metabolically intact cells from mammalian and molluscan neuroendocrine systems have implicated protein phosphatases in this process. In this article David Armstrong and Richard White review these studies and suggest a biochemical pathway that might link one of the G proteins to protein phosphatase activity.

引用

页码：403 / 408

页数：6

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