IMPROVEMENT OF MOUSE BETA-THALASSEMIA BY HYDROXYUREA

被引：17

作者：

SAUVAGE, C ^{[1
]}

ROUYERFESSARD, P ^{[1
]}

BEUZARD, Y ^{[1
]}

机构：

[1] HOP HENRI MONDOR,INSERM,U91,F-94010 CRETEIL,FRANCE

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 84卷 / 03期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb03106.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present report provides evidence that hydroxyurea (HU) improves the beta thalassaemic phenotype in mice receiving 200 mg/kg/d for 30 d. The haematocrit rose from 29 +/- 3% at day 0 to 37 +/- 4% at day 30 (P<0.05), despite myelosuppression and decreased reticulocyte counts. The beta minor/alpha ratio of globin chain synthesis increased from 0.78 at day 0 to 0.97 at day 30 (P<0.001). Membrane defects improved: the proportion of bound alpha chains decreased, the proportion of spectrin and ankyrin increased and red cell deformability also increased.

引用

页码：492 / 496

页数：5

共 21 条

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