APOLIPOPROTEIN EPSILON-4 HOMOZYGOSITY IN YOUNG MEN WITH CORONARY HEART-DISEASE

被引：175

作者：

VANBOCKXMEER, FM

MAMOTTE, CDS

机构：

[1] Department of Biochemistry, Royal Perth Hospital, Perth, WA 6001

来源：

LANCET | 1992年 / 340卷 / 8824期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1016/0140-6736(92)93288-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have compared apolipoprotein E gene polymorphism in 91 Australian men aged 30-50 who had been referred for coronary angioplasty and in 172 healthy younger men. 5 of the 19 patients who were less than 40 years of age were homozygous for the epsilon4 allele, representing a 16-fold increase in prevalence compared with controls. In patients aged 40-50 the epsilon4 allele frequency was 60% higher than it was in controls. Inheritance of epsilon4 seems to confer risk of premature ischaemic heart disease in males, homozygotes being especially at risk at a younger age.

引用

页码：879 / 880

页数：2

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