ON THE RELATIONSHIP BETWEEN FREE PLASMA AND SALIVA AMITRIPTYLINE AND NORTRIPTYLINE

被引:11
作者
BAUMANN, P
TINGUELY, D
KOEB, L
SCHOPF, J
LE, PK
机构
来源
INTERNATIONAL PHARMACOPSYCHIATRY | 1982年 / 17卷 / 03期
关键词
D O I
10.1159/000468569
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Conflicting results on the correlation of tricyclic levels in [human] plasma and saliva have raised doubts about the clinical usefulness of monitoring these drugs in the latter body fluid. Saliva drug levels may reflect the free plasma concentration, which possibly determines its level in the brain. In 2 groups of depressive patients, the evolution was studied of the levels of amitriptyline and nortriptyline in plasma (as free and total) and in saliva, after the administration of amitriptyline. A poor correlation between total plasma and saliva concentration of amitriptyline, respectively, was noted. Levels of both tricyclics in saliva exceed by far those measured in plasma dialysate. The relationship is such that free plasma concentrations may be predicted from those measured in saliva, if saliva pH at the moment of collecting the sample is taken into account.
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收藏
页码:136 / 146
页数:11
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